Why Shop It Here

iS Clinical Skincare

Clinical-grade skincare chosen by a licensed esthetician. Shop online with free shipping over $150, or in person at the studio in Rock Hill, SC.

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Authorized Retailer

Refined with Caroline is an authorized iS Clinical retailer, so what you buy here comes from the brand, not a third-party reseller.

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Used in the Treatment Room

Caroline performs the iS Clinical Fire & Ice Facial in her Rock Hill studio, so she knows these formulas on real skin.

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A Routine Built for You

Not sure where to start? A skin care consultation builds your routine around what your skin needs.

iS Clinical Active Serum
The Brand

Founded on Evidence-Based Science

iS Clinical was founded in 2000 by biochemist Bryan Johns and Alec Call. The brand creates its formulas in its own labs and manufactures every product in-house in Mesa, Arizona.

Its routine is built on four steps, Cleanse, Treat, Hydrate and Protect, using multitasking products. Dermatologists, plastic surgeons and skincare professionals around the world carry it.

What Sets It Apart

The iS Clinical Difference

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Made In-House

Formulated in iS Clinical's own labs and manufactured at its own facility in Mesa, Arizona.

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Clinically Studied

The brand supports its formulas with independent, peer-reviewed clinical studies.

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Clean and Cruelty-Free

iS Clinical states its formulas are free from parabens, phthalates and sulfates, and never tested on animals.

In the Studio

The Fire & Ice Facial

Known as the red carpet facial: intensive resurfacing followed by a cooling, rejuvenating masque, with no downtime. Performed by Caroline in her private studio.

From $173 · 60 minutes

Book Fire & Ice Book a Consultation
A client receiving a facial at Skin by Caroline in Rock Hill, SC

The Refined Edit

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